Contact

Bianca Schmid
Bianca Schmid
Research Technician
Phone: +49 (0) 89-30622-314

Award

Bianca Schmid wins the second prize with her CLARITY animation “Mouse Hippocampus”.

Max-Planck-Award 2014 | Hidden Treasures?

December 01, 2014

Bianca Schmid wins the second prize with her CLARITY animation “Mouse Hippocampus”. [more]
Cover Image connexi 3-2015 Zoom Image
Cover Image connexi 3-2015

CLARITY and Brain Microscopy

Grafik

Our Core Unit applies and develops a new method, called CLARITY, which can be used to transform biological tissue into a transparent hydrogel construct while keeping the native structure as well as the molecular information intact. This for the first time enables optical and molecular analyses at the same time in a whole brain.

The technique is based on the replacement of lipid bilayers with a nanoporous hydrogel that increases the tissue permeability. This enables multiple rounds of immunostaining and/or in situ hybridization in a whole mouse brain, without sectioning the tissue into thin slices.

CLARITY will therefore be critical in expanding our understanding of the brain and of neuronal processes.

 
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