Sleep and Telemetry

Impaired sleep is often comorbid with affective disorders. This Core Unit applies polysomnography in various mouse models of the disease and evaluates how closely they mimic human symptoms based on altered sleep-wake activity and electroencephalogram (EEG) power spectra.

Stress affects sleep. In turn, chronically disrupted sleep affects daily performance and eventually impairs mental health. Changes in sleep patterns indeed precede symptoms. Sleep recordings and analysis are a few behavioral readouts that can be similarly done both in humans and animals. Examining sleep-wake activity in animal models of stress-related disorders is important for understanding mechanisms that link sleep and mood regulation.

  • Long-term EEG and electromyogram (EMG) recordings in freely moving mice via an electric swivel system
  • Monitoring brain temperature (Tbr) included in our polysomnography
  • Sleep recordings and data analyses done by a custom-made LabVIEW (National Instruments) -based program (EGEraVigilanz, SEA, Cologne)
  • Sleep data sampling in group-housed animals with other biosignals (e.g., blood pressure) will be possible (wireless telemetric recordings in preparation)
 
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