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The underlying genetic etiology has been studied over years by linkage, association, and sequencing studies. Neuropathological studies have found disorganized gray and white matter, increased number of neurons, decreased volume of neuronal soma, and increased neuropil. Despite this common underlying neuropathology, the underlying genetic etiology is heterogeneous and complex. Network based approaches may by a way to elicit a common genetic etiology underlying ASD and its diverse phenotypic expression.