- Über uns
- Aktuelles und Öffentlichkeit
We use marker-based high-resolution tracking of rat biological motion to quantitatively and objectively segment and classify its exploratory behaviour. We combine behaviour analysis with multichannel extracellular recording of populations of neurons and oscillatory dynamics in entorhino-hippocampal circuits. We further flexibly manipulate visual world around the rat using newly designed virtual reality system for freely-moving rodents. In the talk I will present our recent advances in these projects along several directions. First, I will show how high-resolution tracking gives rise to quantification of known behaviours and discovery of new behavioural motifs. Second, how population activity of hippocampal neurons is changing dynamically with changes of exploratory states. Third, I will illustrate some applications of the freely moving VR system illustrating the potential of the new method. Fourth, I give an overview of the oscillatory synchronization dynamics across entorhinal-hippocampal circuits. Taken together the constraints imposed by spontaneous exploratory behaviour and network dynamics on activity of hippocampal neurons give rise to a novel temporal framework for the analysis of the mechanisms of memory formation.