Gastgeber und Kontakt

Tobias Wiechmann
Tobias Wiechmann
PhD Student
Telefon: +49 (0) 89-30622-641

Weitere Information

Mehr information über den Gastredner, Onno C. Meijer, finden Sie hier.

Teaser image artwork by Ryuji Yamashita 

Munich Psychiatry Lecture Series | MPLS

13359 1521630554

Brain Corticosteroid Receptors: mechanisms for receptor-, region–, and gene specific signalling

  • Datum: 17.04.2018
  • Uhrzeit: 15:00 - 16:00
  • Vortragender: Onno C. Meijer
  • Div Endocrinology | Dept Internal Medicine | Leiden University Medical Center | The Netherlands
  • Ort: Max Planck Institute of Psychiatry
  • Raum: Lecture Hall
  • Gastgeber: Tobias Wiechmann
  • Kontakt:
Adrenal corticosteroid hormones are potent modulators of the brain via mineralo- and glucocorticoid receptors, MR and GR. MR and GR function in large measure as transcription factors. Not only do they mediate different effects even within the same neurons, these effects may also differ substantially between different (neuronal) cell types. Aberrant MR/GR signalling may be causal to the development of a range of psychopathologies.

The presentation will cover 
1) the discovery of a mechanism for MR-specific transcriptional regulation in hippocampus and consequences for MR dependent target genes, including Fkbp5.
2) the importance of region and gene specific use of downstream coregulator molecules, for example in relation to amygdala Crh regulation. 
3) the possibility to selectively target a subset of GR-dependent processes, using novel Selecitive GR Modulators.

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