Contact

Dr. Michael Mende
Dr. Michael Mende
Program Coordinator IMPRS-TP | EKF-TP
Phone: +49 (0) 89-30622-273
October 2018
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Programme MPLS

More Seminars

Additional seminars and events in the Munich area can be accessed by following the links below:

Munich Neuroscience Lecture Series

Munich Neuroscience Calendar

Life Science Campus Seminars

Seminars

15476 1537778733

Characterization of novel mouse model reveals a new role for FKBP5

Single nucleotide polymorphisms (SNPs) in FK506-binding protein 5 (FKBP5) have been shown to combine with environmental factors increases risk for psychiatric diseases, like post-traumatic stress disorder (PTSD). While mechanisms of FKBP5 contribution to this increased risk are still under investigation, it has been shown that many of these SNPs increase FKBP5 expression through decreased FKBP5 DNA methylation. To evaluate the consequences of this enhanced expression, we generated a novel mouse model using targeted insertion of a single copy of the FKBP5 gene at the Hipp11 locus. The inserted FKBP5 contained a tetracycline operator, which allowed for high expression throughout the forebrain when crossed with an activator line. Evaluation of this model was done using behavioral, electrophysiological, and biochemical analysis. Overall, we have found that high expression of FKBP5 alters memory as tested by both Morris water maze and long-term depression. Importantly, this alteration was detectable in the absence of stress and other environmental factors. Further studies in this model may help reveal additional mechanisms by which FKBP5 alters learning and memory. [more]

Munich Psychiatry Lecture Series | MPLS

14879 1533548975

Personalized medicine in Depression: hype or hope?

Symptom profiles, etiology and course trajectories of Major Depressive Disorder (MDD) are heterogeneous. This heterogeneity is hampering scientific research and is limiting effectiveness of therapeutic interventions. The goal of precision medicine is to tailor medical treatment to the individual characteristics of each patient. In order to implement precision medicine in depression care, it is essential to better understand what the driving factors are behind MDD’s heterogeneity. However, examining MDD’s heterogeneity is no sinecure, and there are various different ways to start such scientific explorations. One could start with data-driven or hypothesis-driven approaches, one could start with a focus on the heterogeneity at the symptom level, the environment level or the pathophysiology level. Ideally, whatever the starting point is should not matter and results of different starting points should synchronize. Using several different analytical approaches, our research group has illustrated the distinction of immunometabolic depression as a potentially useful subtype of depression. [more]

Munich Psychiatry Lecture Series | MPLS

15811 1539935006

Central amygdala circuits that regulate appetite behavior

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Munich Psychiatry Lecture Series | MPLS

15813 1539936245

Neural control of human defensive reactions to social threat

The ability to control automatic emotional actions constitutes a critical component of emotion regulation during socially threatening situations. For instance, under acute social threat, goal directed decision-making depends largely on the capacity to override automatic defensive actions such as freezing reactions or fight-or-flight actions. Distinct parts of the frontal cortex are implicated in regulating these defensive reactions. [more]

 
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