Scientific Core Units

In this Core Unit, the most advanced analytical methods of measurement are used to detect individual and multiple analytes for various research projects by examining material from human and animal sources. To this end, we employ routine methods of clinical analytics, immunological/multi-analyte methods of measurement and chromatography in conjunction with mass spectroscopy.

Analytics and Mass Spectrometry

In this Core Unit, the most advanced analytical methods of measurement are used to detect individual and multiple analytes for various research projects by examining material from human and animal sources. To this end, we employ routine methods of clinical analytics, immunological/multi-analyte methods of measurement and chromatography in conjunction with mass spectroscopy. [more]
The Behavior and Physiology Core Unit provides behavioural set-ups and experimental expertise for running numerous different behavioural tests in mice.

Behavior and Physiology

The Behavior and Physiology Core Unit provides behavioural set-ups and experimental expertise for running numerous different behavioural tests in mice. [more]
The Core Unit Biobanking collects and stores biological samples from patients and healthy subjects. The sample material is processed using appropriate methods to obtain DNA, RNA and PBMC's. Subsequently, samples are quantified and tested for purity and quality. A quality management system for sample processing, storage and documentation is in place

BioPRep

The Core Unit Biobanking collects and stores biological samples from patients and healthy subjects. The sample material is processed using appropriate methods to obtain DNA, RNA and PBMC's. Subsequently, samples are quantified and tested for purity and quality. A quality management system for sample processing, storage and documentation is in place [more]
CLARITY is a new method that turns intact brain tissue into an optically transparent hydrogel-hybrid form by using a chemical treatment. This unique technique allows a three-dimensional view of neuronal networks in combination with molecular analyses in a whole mouse brain. CLARITY can be seen as a new approach in Neuroscience.

CLARITY and Brain Microscopy

CLARITY is a new method that turns intact brain tissue into an optically transparent hydrogel-hybrid form by using a chemical treatment. This unique technique allows a three-dimensional view of neuronal networks in combination with molecular analyses in a whole mouse brain. CLARITY can be seen as a new approach in Neuroscience. [more]
The Electrophysiology Core Unit performs research on single-cell and neuronal network-level electrophysiological processes in the mouse brain. For this purpose, we use field potential and patch-clamp recordings, voltage-sensitive dye imaging, optogenetic tools, etc.

Electrophysiology

The Electrophysiology Core Unit performs research on single-cell and neuronal network-level electrophysiological processes in the mouse brain. For this purpose, we use field potential and patch-clamp recordings, voltage-sensitive dye imaging, optogenetic tools, etc. [more]
The GEMMs Core Unit (Genetically Engineered Mouse Models) provides expertise on the design, generation, maintenance and practical application of genetically engineered mouse models.

GEMMs

The GEMMs Core Unit (Genetically Engineered Mouse Models) provides expertise on the design, generation, maintenance and practical application of genetically engineered mouse models. [more]
Microdialysis Laboratory (MiLAB) is a Core Unit for accomplishing brain microdialysis in mice and subsequent analysis of monoamines, amino acids, acetylcholine and corticosterone in dialysate.

MiLAB

Microdialysis Laboratory (MiLAB) is a Core Unit for accomplishing brain microdialysis in mice and subsequent analysis of monoamines, amino acids, acetylcholine and corticosterone in dialysate. [more]
The Neuroimaging Core Unit provides expertise for all state-of-the-art MRI applications, including structural and functional imaging, simultaneous assessment of fMRI and electrophysiological data, diffusion (spectral) imaging and <sup>1</sup>H-MR spectroscopy.

Neuroimaging

The Neuroimaging Core Unit provides expertise for all state-of-the-art MRI applications, including structural and functional imaging, simultaneous assessment of fMRI and electrophysiological data, diffusion (spectral) imaging and 1H-MR spectroscopy. [more]
The Proteomics Core Unit uses mass spectrometry in combination with protein microchemistry technologies for the fractionation, characterization and quantification of proteins and peptides from complex biological samples.

Proteomics

The Proteomics Core Unit uses mass spectrometry in combination with protein microchemistry technologies for the fractionation, characterization and quantification of proteins and peptides from complex biological samples. [more]
Impaired sleep is often comorbid with affective disorders. This Core Unit applies polysomnography in various mouse models of the disease and evaluates how closely they mimic human symptoms based on altered sleep-wake activity and electroencephalogram (EEG) power spectra.

Sleep and Telemetry

Impaired sleep is often comorbid with affective disorders. This Core Unit applies polysomnography in various mouse models of the disease and evaluates how closely they mimic human symptoms based on altered sleep-wake activity and electroencephalogram (EEG) power spectra. [more]
The Virus Production Core Unit is concerned with the production of viral vectors and their incorporation into a suitable host organism.

Virus Production

The Virus Production Core Unit is concerned with the production of viral vectors and their incorporation into a suitable host organism. [more]
 
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