FKBP51 – a new target for the treatment of depression
Research report (imported) 2008 - Max Planck Institute of Psychiatry
The FK506-binding protein 51 (FKBP51) regulates the signal transduction of steroid hormone receptors and is genetically associated with a variety of affective disorders. Two key steps for a better understanding of this protein in mammalian behaviour are the characterization of transgenic mice and the development of specific inhibitors. The latter further have the potential to study the role of FKBP51 in clinical studies.