CRH-dependent neural circuits modulate the stress response

Research report (imported) 2022 - Max Planck Institute of Psychiatry

Chang, Simon; Du, Ying; Ries, Clemens; Zhao, Chen; Deussing, Jan M.
Abteilung „Molekulare Neurogenetik“
The neuropeptide corticotropin-releasing hormone (CRH) is a central regulator of the stress response. Alterations in the CRH system have repeatedly been observed in depressed patients. Our group at the Max Planck Institute of Psychiatry identified CRH-related circuits shaping anxiety, arousal and locomotion. The detailed comprehension of CRH-dependent neural circuits is a prerequisite to establish the CRH system as a potential alternative therapeutic target beyond classical antidepressants.

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