18497 1574160314

Brain inhibitory GABAergic function and cognitive deficits in depression and during aging: Mechanisms and therapeutic targeting

Changes in the brain excitation inhibition balance characterize neuropsychiatric disorders and aging. Using human post-mortem samples and genetic rodent models, combined with genomic and bioinformatics approaches, we have reported changes in GABAergic inhibitory neurons that target pyramidal cell dendrites in human depression and aging, and associated these changes with cognitive and mood behaviors in rodent models. [more]
22494 1572954970

Modeling cellular responses in single cell genomics

Munich Psychiatry Lecture Series | MPLS
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