18496 1574160373

Brain inhibitory GABAergic function and cognitive deficits in depression and during aging: Mechanisms and therapeutic targeting

Changes in the brain excitation inhibition balance characterize neuropsychiatric disorders and aging. Using human post-mortem samples and genetic rodent models, combined with genomic and bioinformatics approaches, we have reported changes in GABAergic inhibitory neurons that target pyramidal cell dendrites in human depression and aging, and associated these changes with cognitive and mood behaviors in rodent models. [mehr]
22495 1572954858

Modeling cellular responses in single cell genomics

Munich Psychiatry Lecture Series | MPLS
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