Study designed to identify biomarkers for mental disorders
Psychiatrists usually cannot rely on biological parameters when making a diagnosis. A physician diagnoses an inflammation based on a blood test, an orthopedist observes a fracture on the X-ray image. A psychiatrist’s job, however, is much harder since the brain is such a complex organ. Within the scope of the BeCOME study, we investigate if such objective data can provide additional diagnostic information on mental disorders and if so, what kind of data. To implement this study, we are looking for outpatients and healthy controls.
The main focus of the investigation program is to image certain brain processes. “Especially with regard to its broad spectrum, our approach is a worldwide novelty and it is based on scientific results of the past years,” emphasizes Dr. Dr. med. univ. Elisabeth Binder, Director of the Max Planck Institute of Psychiatry and leader of the study in collaboration with Prof. Dr. Dr. Martin E. Keck, Head of the Hospital of the Max Planck Institute of Psychiatry. “In a unique concept, we collect data not only by asking how the patients feel but also by gathering genetic and epigenetic data as well as several body parameters and brain functions,” Keck summarizes.
Such investigations can only be performed by combining the expertise from many biomedical sections with the respective latest technologies. The Max Planck Institute of Psychiatry upholds a uniquely close interaction between basic science, clinical research, and clinical services, which facilitates conducting such complex studies with the objective of developing novel treatment offers for mental disorders.
Course of the study
On two consecutive days, multiple examinations are carried out:
- Recording of symptoms by means of psychological questionnaires
- Magnetic resonance imaging
- Psychophysiological recordings
- Laboratory diagnostics (for this purpose, we take blood samples)
In addition, participants in our study will wear an actigraph or a fitness tracker on their wrist for about 28 days. It will record their movements and inform us on their sleep and waking phases.
Both healthy controls and (in- and out-) patients with non-acute psychiatric disorders who are currently not taking psychotropic drugs are allowed to participate in our study. More information can be found here.