Dr. Michael Mende
Dr. Michael Mende
Program Coordinator IMPRS-TP | EKF-TP
Telefon: +49 (0) 89-30622-273

Programm MPLS


Weitere Seminare

Weitere Ankündigungen zu Seminaren und Veranstaltungen im Raum München finden sich unter folgenden Verlinkungen:

Munich Neuroscience Lecture Series

Munich Neuroscience Calendar

Life Science Campus Seminars


Munich Psychiatry Lecture Series | MPLS

11553 1516091079

Fighting Alzheimer’s disease by empowering the innate and adaptive immune system

It has become clear that brain immunity encompasses the resident myeloid cells, the microglia, and well as circulating adaptive and innate immune cells, that are located in special compartments at the brain's borders, including the meninges and the choroid plexus. These circulating immune cells support brain repair and functional plasticity. Specifically, we found that the epithelial layer that forms the blood-CSF-barrier, the choroid plexus epithelium (CP), serves as a gate regulating leukocyte entry to the CNS; its activity is controlled by its cytokine milieu, and specifically IFN-γ. In analyzing how the activity of this interface determines the fate of the brain, we discovered by immunogenomics and immunohistochemistry that in aging and in Alzheimer’s disease (AD) mouse models, this interface is suppressed with respect to its ability to allow communication between the brain and the circulating leukocytes. [mehr]

Munich Psychiatry Lecture Series | MPLS

11833 1515495541

Brain oxytocin and neuropeptide S: From social preference to social fear

The neuropeptides oxytocin (OXT) and neuropeptide S (NPS) have gained substantial interest as important modulators of socio-emotional behaviours. As such, both OXT and NPS exert anxiolytic effects also in rats selectively bred for high (HAB) versus low (LAB) anxiety-related behaviour, and were found to reverse non-social fear in models of cued fear-conditioning. Moreover, both neuropeptides are major players in the promotion of social interactions. For example, I will present data demonstrating that naturally occurring social preference behaviour is highly OXT-dependent both in laboratory rats and mice, and that social defeat-induced avoidance of conspecifics is reversed by each of these neuropeptides1,2. [mehr]

Munich Psychiatry Lecture Series | MPLS

11847 1513339423

The making and keeping of memory

tba [mehr]

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