Magnetic resonance imaging techniques have been established as a unique diagnostic tool in psychiatry and neurology, allowing for non-invasive assessment of structural, functional and metabolic markers in patients, as well as in animal models of psychiatric and neurological disorders. The evaluation of the intact living brain in animal models constitutes an important step in translational research, linking preclinical findings to symptoms/observations in patients, and vice versa. Longitudinal measurements are conducted to characterize vulnerability or resilience to psychiatric disorders, to monitor disease progression, and to evaluate effects of therapeutic interventions.

3 Tesla system

The following list, which is not exhaustive, gives examples of specific human MR acquisition protocols:

  • Structural MRI (sMRI) including high-resolution anatomical scans
  • Diffusion MRI (diffusion weighted imaging [DWI], diffusion tensor imaging [DTI], diffusion spectral imaging [DSI])
  • Functional MRI (task-based fMRI, resting-state fMRI, EEG-informed fMRI)
  • Quantitative MRI (T1-, T2-relaxometry)
  • Perfusion imaging (e.g., arterial spin labelling [ASL]) and angiography (with or without contrast agents)
  • Whole body MRI (e.g., visceral fat quantification)
  • Magnetic resonance spectroscopy (single-voxel 1H-MRS, chemical shift imaging [CSI])
  • Combined measurements (EEG/fMRI, polysomnography/fMRI, startle EMG/fMRI, skin conductance/fMRI)

9.4 Tesla system

A main focus of the preclinical system lies on the following applications:

  • Structural MRI (high-resolution anatomical scans (~ 80 µm))
  • MR-microscopy (high-resolution (isotropic ~50 µm) ex vivo mouse brain MRI, gadolinium- or manganese-enhanced)
  • MEMRI (Manganese enhanced MRI for structural or functional characterization)
  • functional MRI (BOLD, resting state)
  • MRS (single-voxel 1H-MRS)
  • Whole body MRI (e.g., visceral fat quantification)
Go to Editor View