Publications of Simone Roeh

Castro-Quintas, A.; Palma-Gudiel, H.; Eixarch, E.; Gonzalez, N. S. M.; Roeh, S.; Sauer, S.; Rex-Haffner, M.; Monteserin-Garcia, J. L.; de la Fuente-tomas, L.; Crispi, F. et al.; Portilla, M. P. G.; Binder, E. B.; Fananas, L.: Placental epigenetic signatures of maternal distress in glucocorticoid-related genes and newborn outcomes: A study of Spanish primiparous women. EUROPEAN NEUROPSYCHOPHARMACOLOGY 90, pp. 36 - 47 (2025)

Hagenberg, J.; Brueckl, T. M.; Erhart, M.; Kopf-Beck, J.; Koedel, M.; Rehawi, G.; Roeh-Karamihalev, S.; Sauer, S.; Yusupov, N.; Rex-Haffner, M. et al.; Spoormaker, V. I.; Saemann, P. G.; Binder, E. B.; Knauer-Arloth, J.: Dissecting depression symptoms: Multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulation. BRAIN BEHAVIOR AND IMMUNITY 123, pp. 353 - 369 (2025)

Froehlich, A. S.; Gerstner, N.; Gagliardi, M.; Ködel, M.; Yusupov, N.; Matosin, N.; Czamara, D.; Sauer, S.; Roeh, S.; Murek, V. et al.; Chatzinakos, C.; Daskalakis, N. P.; Knauer-Arloth, J.; Ziller, M. J.; Binder, E. B.: Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease. NATURE NEUROSCIENCE 27, pp. 2021 - 2032 (2024)

Grossmann, N. L.; Weihs, A.; Kuehn, L.; Sauer, S.; Roeh, S.; Wiechmann, T.; Rex-Haffner, M.; Voelzke, H.; Voelker, U.; Binder, E. B. et al.; Teumer, A.; Homuth, G.; Klinger-Koenig, J.; Grabe, H. J.: Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 (3), 1485 (2024)

Karlbauer, V. N.; Martins, J.; Rex-Haffner, M.; Sauer, S.; Roeh, S.; Dittrich, K.; Doerr, P.; Klawitter, H.; Entringer, S.; Buss, C. et al.; Winter, S. M.; Heim, C.; Czamara, D.; Binder, E. B.: Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated children. NEUROBIOLOGY OF STRESS 33, 100687 (2024)

Krontira, A. C.; Cruceanu, C.; Dony, L.; Kyrousi, C.; Link, M.-H.; Rek, N.; Pöhlchen, D.; Raimundo, C.; Penner-Goeke, S.; Schowe, A. et al.; Czamara, D.; Lahti-Pulkkinen, M.; Sammallahti, S.; Wolford, E.; Heinonen, K.; Roeh, S.; Sportelli, V.; Woelfel, B.; Koedel, M.; Sauer, S.; Rex-Haffner, M.; Raikkonen, K.; Labeur, M.; Cappello, S.; Binder, E. B.: Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression. NEURON 112 (9), pp. 1426 - 1443.e11 (2024)

Yusupov, N.; Roeh, S.; Sotillos Elliott, L.; Chang, S.; Loganathan, S.; Urbina Trevino, L.; Fröhlich, A. S.; Sauer, S.; Ködel, M.; Matosin, N. et al.; Czamara, D.; Deussing, J. M.; Binder, E. B.: DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans. MOLECULAR PSYCHIATRY (2024)

Penner-Goeke, S.; Bothe, M.; Rek, N.; Kreitmaier, P.; Poehlchen, D.; Kühnel, A.; Glaser, L. V.; Kaya, E.; Krontira, A.; Roeh, S. et al.; Czamara, D.; Ködel, M.; Monteserin-Garcia, J.; Diener, L.; Woelfel, B.; Sauer, S.; Rummel, C.; Riesenberg, S.; Arloth-Knauer, J.; Ziller, M.; Labeur, M.; Meijsing, S.; Binder, E. B.: High- throughput screening of glucocorticoid- induced enhancer activity reveals mechanisms of stress- related psychiatric disorders. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 (49), e2305773120 (2023)

Yusupov, N.; van Doeselaar, L.; Roeh, S.; Wiechmann, T.; Koedel, M.; Sauer, S.; Rex-Haffner, M.; Schmidt, M. V.; Binder, E. B.: Extensive evaluation of DNA methylation of functional elements in the murine Fkbp5 locus using high-accuracy DNA methylation measurement via targeted bisulfite sequencing. EUROPEAN JOURNAL OF NEUROSCIENCE (2023)

Cruceanu, C.; Dony, L.; Krontira, A. C.; Fischer, D. S.; Roeh, S.; Di Giaimo, R.; Kyrousi, C.; Kaspar, L.; Arloth, J.; Czamara, D. et al.; Gerstner, N.; Martinelli, S.; Wehner, S.; Breen, M. S.; Koedel, M.; Sauer, S.; Sportelli, V.; Rex-Haffner, M.; Cappello, S.; Theis, F. J.; Binder, E. B.: Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study. AMERICAN JOURNAL OF PSYCHIATRY 179 (5), pp. 375 - 387 (2022)

Gerstner, N.; Krontira, A. C.; Cruceanu, C.; Roeh, S.; Puetz, B.; Sauer, S.; Rex-Haffner, M.; Schmidt, M. V.; Binder, E. B.; Knauer-Arloth, J.: DiffBrainNet: Differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions. NEUROBIOLOGY OF STRESS 21, 100496 (2022)

Kvist, T.; Sammallahti, S.; Lahti-Pulkkinen, M.; Cruceanu, C.; Czamara, D.; Dieckmann, L.; Tontsch, A.; Roh, S.; Rex-Haffner, M.; Wolford, E. et al.; Reynolds, R.; Eriksson, J.; Suomalainen-Konig, S.; Laivuori, H.; Kajantie, E.; Lahdensuo, E.; Binder, E.; Raikkonen, K.: Cohort profile: InTraUterine sampling in early pregnancy (ITU), a prospective pregnancy cohort study in Finland: study design and baseline characteristics. BMJ OPEN 12 (1), e049231 (2022)

Lopez, J. P.; Luecken, M. D.; Brivio, E.; Karamihalev, S.; Kos, A.; De Donno, C.; Benjamin, A.; Yang, H.; Dick, A. L. W.; Stoffel, R. et al.; Flachskamm, C.; Ressle, A.; Roeh, S.; Huettl, R. E.; Parl, A.; Eggert, C.; Novak, B.; Yan, Y.; Yeoh, K.; Lebar, M.; Hauger, B.; Harbich, D.; Schmid, B.; Di Giaimo, R.; Turck, C. W.; Schmidt, M. V.; Deussing, J. M.; Eder, M.; Dine, J.; Theis, F. J.; Chen, A.: Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. NEURON 110 (14), pp. 2283 - 2298.e9 (2022)

Womersley, J. S.; Roeh, S.; Martin, L.; Ahmed-Leitao, F.; Sauer, S.; Rex-Haffner, M.; Hemmings, S. M. J.; Binder, E. B.; Seedat, S.: FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents. BRAIN STRUCTURE & FUNCTION 227 (8), pp. 2809 - 2820 (2022)

Hausl, A. S.; Brix, L.; Hartmann, J.; Poehlmann, M. L.; Lopez, J. P.; Menegaz, D.; Brivio, E.; Engelhardt, C.; Roeh, S.; Bajaj, T. et al.; Rudolph, L.; Stoffel, R.; Hafner, K.; Goss, H. M.; Reul, J. M. H. M.; Deussing, J. M.; Eder, M.; Ressler, K. J.; Gassen, N. C.; Chen, A.; Schmidt, M. V.: The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice. MOLECULAR PSYCHIATRY (2021)

Czamara, D.; Dieckmann, L.; Roeh, S.; Kraemer, S.; Rancourt, R. C.; Sammallahti, S.; Kajantie, E.; Laivuori, H.; Eriksson, J. G.; Raikkonen, K. et al.; Henrich, W.; Plagemann, A.; Binder, E. B.; Braun, T.; Entringer, S.: Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation. CLINICAL EPIGENETICS 13 (1), 165 (2021)

Lopez, J. P.; Brivio, E.; Santambrogio, A.; De Donno, C.; Kos, A.; Peters, M.; Rost, N.; Czamara, D.; Brueckl, T.; Roeh, S. et al.; Poehlmann, M. L.; Engelhardt, C.; Ressle, A.; Stoffel, R.; Tontsch, A.; Villamizar, J. M.; Reincke, M.; Riester, A.; Sbiera, S.; Fassnacht, M.; Mayberg, H. S.; Craighead, W. E.; Dunlop, B. W.; Nemeroff, C. B.; Schmidt, M. V.; Binder, E. B.; Theis, F. J.; Beuschlein, F.; Andoniadou, C. L.; Chen, A.: Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation. SCIENCE ADVANCES 7 (5), eabe4497 (2021)

Dick, A. L. W.; Zhao, Q.; Crossin, R.; Baker-Andresen, D.; Li, X.; Edson, J.; Röh, S.; Marshall, V.; Bredy, T. W.; Lawrence, A. J. et al.; Duncan, J. R.: Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex. ADDICTION BIOLOGY, e12937 (2020)

Provencal, N.; Arloth, J.; Cattaneo, A.; Anacker, C.; Cattane, N.; Wiechmann, T.; Roeh, S.; Koedel, M.; Klengel, T.; Czamara, D. et al.; Mueller, N. S.; Lahti, J.; Raikkonen, K.; Pariante, C. M.; Binder, E. B.: Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (38), pp. 23280 - 23285 (2020)

Cruceanu, C.; Dony, L.; Kontira, A. C.; Fischer, D.; Roeh, S.; Di Giaimo, R.; Cappello, S.; Theis, F.; Binder, E. B.: Brain organoids as models of the developing human brain: deciphering the molecular signature of prenatal stress. EUROPEAN NEUROPSYCHOPHARMACOLOGY 29, pp. S7 - S8 (2019)