Publications Janine Knauer-Arloth

Gerstner, N.; Frohlich, A. S.; Matosin, N.; Gagliardi , M.; Cruceanu, C.; Kodel, M.; Rex-Haffner, M.; Tu, X.; Mostafavi, S.; Ziller, M. J. et al.; Binder, E. B.; Knauer-Arloth, J.: Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC. Science advances 11 (10), eadq2290 (2025)

Hagenberg, J.; Brueckl, T. M.; Erhart, M.; Kopf-Beck, J.; Koedel, M.; Rehawi, G.; Roeh-Karamihalev, S.; Sauer, S.; Yusupov, N.; Rex-Haffner, M. et al.; Spoormaker, V. I.; Saemann, P. G.; Binder, E. B.; Knauer-Arloth, J.: Dissecting depression symptoms: Multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulation. BRAIN BEHAVIOR AND IMMUNITY 123, pp. 353 - 369 (2025)

Knauer-Arloth, J.; Hryhorzhevska, A.; Binder, E. B.: Multiomics Analysis of the Molecular Response to Glucocorticoids: Insights Into Shared Genetic Risk From Psychiatric to Medical Disorders. Biological psychiatry 97 (8), pp. 794 - 805 (2025)

van Doeselaar, L.; Abromeit, A.; Stark, T.; Menegaz, D.; Ballmann, M.; Mitra, S.; Yang, H.; Rehawi, G.; Huettl, R. E.; Bordes, J. et al.; Narayan, S.; Harbich, D.; Deussing, J. M.; Rammes, G.; Czisch, M.; Knauer-Arloth, J.; Eder, M.; Lopez, J. P.; Schmidt, M. V.: FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice. Nature communications 16 (1), 2529 (2025)

Worf, K.; Matosin, N.; Gerstner, N.; Frohlich, A. S.; Koller, A. C.; Degenhardt, F.; Thiele, H.; Rietschel, M.; Udawela, M.; Scarr, E. et al.; Dean, B.; Theis, F. J.; Mueller, N. S.; Knauer-Arloth, J.: Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons. Translational psychiatry 15 (1), 153 (2025)

Arcego, D. M.; Buschdorf, J.-P.; O'Toole, N.; Wang, Z.; Barth, B.; Pokhvisneva, I.; Rayan, N. A.; Patel, S.; de Mendonca Filho, E. J.; Lee, P. et al.; Tan, J.; Koh, M. X.; Sim, C. M.; Parent, C.; de Lima, R. M. S.; Clappison, A.; O'Donnell, K. J.; Dalmaz, C.; Arloth, J.; Provencal, N.; Binder, E. B.; Diorio, J.; Silveira, P. P.; Meaney, M. J.: A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. BIOLOGICAL PSYCHIATRY 95 (1), pp. 48 - 61 (2024)

Froehlich, A. S.; Gerstner, N.; Gagliardi, M.; Ködel, M.; Yusupov, N.; Matosin, N.; Czamara, D.; Sauer, S.; Roeh, S.; Murek, V. et al.; Chatzinakos, C.; Daskalakis, N. P.; Knauer-Arloth, J.; Ziller, M. J.; Binder, E. B.: Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease. NATURE NEUROSCIENCE 27, pp. 2021 - 2032 (2024)

Hagenberg, J.; Budde, M.; Pandeva, T.; Kondofersky, I.; Theis, F. J.; Schaupp, S. K.; Schulze, T. G.; Mueller, N. S.; Heilbronner, U.; Batra, R. et al.; Knauer-Arloth, J.: longmixr: a tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types. BIOINFORMATICS 40 (4), btae137 (2024)

Martinelli, S.; Hafner, K.; Ködel, M.; Knauer-Arloth, J.; Gassen, N. C.; Binder, E. B.: Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 (22), 12318 (2024)

Kuehnel, A.; Hagenberg, J.; Knauer-Arloth, J.; Koedel, M.; Czisch, M.; Saemann, P. G.; Binder, E. B.; Kroemer, N. B.: Stress-induced brain responses are associated with BMI in women. COMMUNICATIONS BIOLOGY 6 (1), 1031 (2023)

Matosin, N.; Arloth, J.; Czamara, D.; Edmond, K. Z.; Maitra, M.; Froehlich, A. S.; Martinelli, S.; Kaul, D.; Bartlett, R.; Curry, A. R. et al.; Gassen, N. C.; Hafner, K.; Mueller, N. S.; Worf, K.; Rehawi, G.; Nagy, C.; Halldorsdottir, T.; Cruceanu, C.; Gagliardi, M.; Gerstner, N.; Ködel, M.; Murek, V.; Ziller, M. J.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J. E.; Weinberger, D. R.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E. B.: Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex. ACTA NEUROPATHOLOGICA 145 (4), pp. 439 - 459 (2023)

Penner-Goeke, S.; Bothe, M.; Rek, N.; Kreitmaier, P.; Poehlchen, D.; Kühnel, A.; Glaser, L. V.; Kaya, E.; Krontira, A.; Roeh, S. et al.; Czamara, D.; Ködel, M.; Monteserin-Garcia, J.; Diener, L.; Woelfel, B.; Sauer, S.; Rummel, C.; Riesenberg, S.; Arloth-Knauer, J.; Ziller, M.; Labeur, M.; Meijsing, S.; Binder, E. B.: High- throughput screening of glucocorticoid- induced enhancer activity reveals mechanisms of stress- related psychiatric disorders. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 (49), e2305773120 (2023)

Czamara, D.; Neufang, A.; Dieterle, R.; Iurato, S.; Arloth, J.; Martins, J.; Ising, M.; Binder, E. B.; Erhardt, A.: Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder. CLINICAL EPIGENETICS 14 (1), 55 (2022)

Cruceanu, C.; Dony, L.; Krontira, A. C.; Fischer, D. S.; Roeh, S.; Di Giaimo, R.; Kyrousi, C.; Kaspar, L.; Arloth, J.; Czamara, D. et al.; Gerstner, N.; Martinelli, S.; Wehner, S.; Breen, M. S.; Koedel, M.; Sauer, S.; Sportelli, V.; Rex-Haffner, M.; Cappello, S.; Theis, F. J.; Binder, E. B.: Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study. AMERICAN JOURNAL OF PSYCHIATRY 179 (5), pp. 375 - 387 (2022)

Gerstner, N.; Krontira, A. C.; Cruceanu, C.; Roeh, S.; Puetz, B.; Sauer, S.; Rex-Haffner, M.; Schmidt, M. V.; Binder, E. B.; Knauer-Arloth, J.: DiffBrainNet: Differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions. NEUROBIOLOGY OF STRESS 21, 100496 (2022)

Kappelmann, N.; Arloth, J.; Georgakis, M. K.; Czamara, D.; Rost, N.; Ligthart, S.; Khandaker, G. M.; Binder, E. B.: Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms A Genetic Correlation and 2-Sample Mendelian Randomization Study. JAMA PSYCHIATRY 78 (2), pp. 161 - 170 (2021)

Kappelmann, N.; Czamara, D.; Rost, N.; Moser, S.; Schmoll, V.; Trastulla, L.; Stochl, J.; Lucae, S.; Binder, E. B.; Khandaker, G. M. et al.; Arloth, J.: Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study. BRAIN BEHAVIOR AND IMMUNITY 95, pp. 256 - 268 (2021)

Moore, S. R.; Halldorsdottir, T.; Martins, J.; Lucae, S.; Mueller-Myhsok, B.; Mueller, N. S.; Piechaczek, C.; Feldmann, L.; Freisleder, F. J.; Greimel, E. et al.; Schulte-Koerne, G.; Binder, E. B.; Arloth, J.: Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation. TRANSLATIONAL PSYCHIATRY 11 (1), 632 (2021)

Ogris, C.; Hu, Y.; Arloth, J.; Mueller, N. S.: Versatile knowledge guided network inference method for prioritizing key regulatory factors in multi-omics data. SCIENTIFIC REPORTS 11 (1), 6806 (2021)

Arloth, J.; Eraslan, G.; Andlauer, T. F. M.; Martins, J.; Iurato, S.; Kuehnel, B.; Waldenberger, M.; Frank, J.; Gold, R.; Hemmer, B. et al.; Luessi, F.; Nischwitz, S.; Paul, F.; Wiendl, H.; Gieger, C.; Heilmann-Heimbach, S.; Kacprowski, T.; Laudes, M.; Meitinger, T.; Peters, A.; Rawal, R.; Strauch, K.; Lucae, S.; Müller-Myhsok, B.; Rietschel, M.; Theis, F. J.; Binder, E. B.; Mueller, N. S.: DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning. PLOS COMPUTATIONAL BIOLOGY 16 (2), e1007616 (2020)