Research Group Developmental Neurobiology
Neurogenesis and neuronal migration are fundamental steps in the development of the brain. Defects in these processes lead to neurodevelopmental disorders and represent a major cause of developmental disabilities and severe epilepsies. In order to understand the biological mechanisms and therefore identify potential therapies for neurodevelopmental disorders, we need to first discover the regulation of all processes of brain development. We combine human brain organoids and animal models to identify the cellular and molecular mechanisms governing brain development and altered in neurodevelopmental disorders.